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Multiple sclerosis is the chronic inflammatory demyelinating disease of central nervous system. It is an autoimmune disorder and is characterized by the production of antibodies that damage the nerve myelin sheath and ultimately the nerve itself. This leads to production of the significant physical disability commonly called as paralysis along with other symptoms like paraesthesia, intention tremor, scanning speech, nystagmus, heat intolerance, bowel and bladder dysfunction, sharp pain, ataxia, tremors and much more.

It has been found that clinical condition named as CCSVI, that is chronic cerebrospinal venous insufficiency is one of the factors that add to the damage of nerves or nervous system in multiple sclerosis.

MULTIPLE SCLEROSIS affects largely the young adults between the age of 20-40 years and is more common in women.
It is an autoimmune disease which is induced by viral and several other infectious agents which lead to increased antibodies in the cerebrospinal fluid that elicits the autoimmune response resulting in nerve damage.

The precise cause of MULTIPLE SCLEROSIS is unknown. However, the following factors play a vital role in progression of the MULTIPLE SCLEROSIS.

Immunological

  • Multiple Sclerosis is autoimmune disease which is believed to be induced by viral or infectious agents leading to breakdown of the immune system that ultimately destroys nervous system.

Genetic

  • Genetic susceptibility plays an important role in development of Multiple Sclerosis. It has been proved that if one of the parents has MS, then their children are at high risk of getting the disease.

Infection

  • Bacterial or viral infection can trigger Multiple Sclerosis as they are responsible and known to cause demyelination. These viruses includes herpes virus 6, chlamydial pneumonia, Epstein-Barr etc.

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